When you get a prescription filled, pharmacists are supposed to ask you if you're on any other medications, and then check to see if there could possibly be any negative interactions between your drug treatments. Unfortunately, they don't always tell you these things, putting you at risk for some scary side effects. They also might not take into consideration any vitamins or supplements you might be taking. Use a drug interaction website to check for possible adverse effects. It's obviously not a replacement for a visit to the doctor's office, but doing some research on your own can give you a good idea of when it's okay to combine medications and when it's a bad idea.
For more information, visit http://www.drugs.com/drug_interactions.html