Sleep is. Get enough sleep the night before. I know, I know, you’re sooo excited about where you’re going but get some sleep. Seriously. If you are gonna be on the road for over 5 hours and doing any night driving you’re gonna need as much sleep as possible.
Extra: try not to go it alone. The radio will begin to make you crazy. Talking to yourself and answering back is a little worrying after the third hour.